9 Quick Ways to Get Relief From Fever Blisters

Fever blisters are also called core sores, usually lasting between 10 and 14 days. The blisters are usually in groups and cause red, swollen, and sore wounds. They often develop near the mouth or other face parts but may also appear on the tongue or gums. The herpes simplex virus causes fever blisters. Approximately 90 percent of the world’s adult population has either HSV-1 or HSV-2. About 65 percent of the people in the United States have been exposed to HSV-1.

Even though fever blister flare-ups can heal independently, there are many effective ways to reduce the pain and promote healing. These include at-home remedies as well as prescription medications.

Lemon Balm

There is evidence that lemon balm kills the herpes simplex virus in some cases and affects how the virus attaches to host cells, according to a 2012 study. To treat the sores, apply diluted lemon balm cream, ointment, or lip balm several times daily. You can also use a cotton ball diluted with essential oil for the sores.

Witch Hazel

Witch hazel is known to reduce inflammation and fight the herpes virus, according to a study. In addition to being an astringent, it dries the area, which may promote healing. Use a moistened cotton ball to apply witch hazel (such as Thayers Organic) directly to the skin. Hold the cotton ball in place using light pressure, and do not rub it.

Apple Cider Vinegar

Despite the lack of evidence linking ACV to herpes, research suggests it may be anti-infective and antifungal. However, its acidic properties and potential to damage tissues should be considered when applying it to wounds. If you are suffering from bacterial skin infections, you should use diluted ACV several times daily on the affected area. You can hold it there for a few minutes.

Prescription Medicine

OTC topical creams aren’t the only option. Prescription antiviral medications are also available. Consult your doctor to see if one of them would be a good choice for you: Acyclovir (Zovirax), Famciclovir, Penciclovir (Denavir), and Valacyclovir (Valtrex). Also, apply a moisturizing cream when your fever blister begins to crust and form a scab. Experts strongly recommend taking or using these medications as early as possible to speed up the healing cycle.

Oregano Oil

Evidence shows that oregano oil inhibits different animal and human viruses, including herpes. However, it needs to be clarified what dose is required to provide benefit. Apply diluted oregano oil several times throughout the day to the affected area.

Kanuka Honey

The healing properties of honey are well known, and a study found that kanuka honey, derived from the manuka tree in New Zealand, could also be effective in treating fever blisters. According to a large randomized clinical trial, a medical-grade version of this honey worked just as well as acyclovir in treating fever blisters.


Ice can reduce inflammation by reducing blood flow to the area and numbing the site, so there is less pain. If you have a fever blister, wrap an ice pack with a towel or cloth and place it on it for no longer than 5 minutes. Please don’t apply ice directly to the skin, as it can result in serious damage. It is a temporary treatment that does not affect the virus or promote healing.

Tea Tree Oil

Tea tree oil reviews suggest that it may be a helpful antiviral treatment. It also aids in speeding up the healing process and limiting plaque formation. Start by adding diluted tea tree oil to a cotton ball. Then, dab it on the sore spot several times per day.


As a preventive and treatment, people report benefits from taking L-lysine, an amino acid that may help shorten fever blister duration. Harvard Health Publications says that lysine inhibits the amino acid that causes fever blisters to form. However, more investigation is needed to confirm its effectiveness. This product may also be effective at limiting fever blister outbreaks.


DISCLAIMER: The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the site owner or any brands and companies mentioned here. Any content provided by our bloggers or authors are of their opinion, and are not intended to malign any religion, ethnic group, club, organization, company, individual or anyone or anything. This article is purely for reference purposes and does not constitute professional advice and may not be reflective of the best choice for your unique situation. This site strives to provide as much accurate information as possible; however, sometimes products, prices, and other details are subject to change. Therefore, this site does not verify for the accuracy of the information presented in this article. This site does not assume any liability for any sort of damages arising from your use of this site and any third party content and services.